03/2015  Francis Lynn

welcome to the lynn lab!

Research in the Lynn lab is targeted at understanding the insulin-producing pancreatic β-cell, how it fails during diabetes mellitus and how we can make surrogate cells to cure diabetes. We use a variety of models to study the regulatory pathways important for embryonic β-cell genesis and function. The β-cell research in the Lynn lab can be broken down into three discrete but interrelated areas:

Transcriptional regulation - how proteins called transcription factors control development and function

Post-transcriptional regulation - how small RNAs called microRNAs control development and function

Interface of transcriptional and post-transcriptional regulation - how microRNAs control development and function through the regulation of transcription